HFS may stand for:
- Hexafluorosilicic acid
- Washington High Fidelity Stereo (WHFS), an FM radio station transmitting from Catonsville, Maryland.
- Hemifacial spasm, a neurologic disorder which causes involuntary spasms in one side of the face.
- Hospitality Franchise Systems, (HFS) later Cendant.
- Haddonfield Friends School, a Quaker school in Haddonfield, NJ.
- Hatfield and Stainforth railway station, England; National Rail station code HFS.
In computing
- Hardware Functionality Scan
- Hi Performance FileSystem, a file system used by the HP-UX operating system
- Hierarchical File System, a file system used by Apple Macintosh computers.
- HTTP File Server
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